Official Jojo Siwa Deluxe Bows and Pom Pom Keyring Maker - Brand New

In 2016, Siwa collaborated with the fashion accessory and jewellery firm Claire's to create a series of hair bows that were sold exclusively at Claire's. Among primary school students in the United Kingdom, the line of hair bows, which was inspired by the hairbows Siwa is known for wearing, found particular success. However, some schools have taken to banning them for a variety of reasons, such as peer pressure, causing distraction from schoolwork, impairing pupils' concentration, and violating school dress policies. As a result of the popularity of the bows, other retailers started selling bows that were identical to them. Siwa said in 2017 that her bows were a "sign of power, confidence, and believing-ness," and that they were "a mark of strength, confidence, and believing-ness."

Siwa then formed a partnership with the American department retailer J. C. Penney, resulting in the sale of an accessory line, bedroom décor, and a doll created in her image, as well as the publication of many novels geared toward young children.

After signing with Nickelodeon in 2017, Siwa appeared in the film Blurt! with Jace Norman and the programme Lip Sync Battle Shorties alongside Nick Cannon. Afterwards, Siwa participated as "T-Rex" in season 3 of the television show The Masked Singer. She was the youngest competitor to participate on the programme until Honey Boo Boo appeared as one half of the duo "Beach Ball" in season six, at which point she became the youngest participant again. Siwa was a playable character in the video game Nickelodeon Kart Racers 2: Grand Prix, which was released in 2020.

In January 2021, Spin Master released a card game called "JoJo's Juice," which included questions regarding nudity and stealing, despite the fact that it was intended for children aged 6 and above. Following an apology by Siwa, who claimed she had not been involved in the production of the game's content, the game was pulled from all toy shop shelves.

She was named one of the 100 Most Influential People in the World by TIME Magazine.